Epilepsy Research
Volume 23, Issue 3 , Pages 225-233 , April 1996

Effects of chronic morphine pretreatment on amygdaloid kindling development, postictal seizure and suppression and benzodiazepine receptor binding in rats

  • L. Rocha

      Affiliations

    • Corresponding Author InformationCorresponding author. Instituto Mexicano de Psiquiatría, Division de Neurociencias, Av. México-Xochimilco 101, C.P. 14370, México D.F.
    • Instituto Mexicano de Psiquiatría, Mexico City, Mexico
  • ,
  • R.F. Ackermann

      Affiliations

    • Brain Research Institute, UCLA, Los Angeles, California, USA
    • Department of Neurology, UCLA, Los Angeles, California, USA
  • ,
  • J. Engel Jr.

      Affiliations

    • Department of Neurology, UCLA, Los Angeles, California, USA
    • Department of Anatomy and Cell Biology, UCLA, Los Angeles, California, USA

Received 11 January 1995 ,Accepted 6 July 1995.

References 

  1. Adamec RE, Stark-Adamec C. Limbic kindling and animal behavior—Implications for human psychopathology associated with complex partial seizures. Biol. Psychiatry. 1983;18:269–293
  2. Ahlijanian MK, Takemori AE. Changes in adenosine receptor sensitivity in morphine-tolerant and -dependent mice. J. Pharmacol. Exp. Ther. 1986;236:615–620
  3. Antkiewicz-Michaluk L, Michaluk J, Marona-Lewicka D, Vetulani J. The effect of morphine dependence and abstinence on opioid receptors in the cerebral cortex and spinal cord of the rat. Pol. J. Pharmacol. Pharm. 1988;40:11–16
  4. Breuker E, Dingledine R, Iversen LL. Evidence for naloxone and opiates as GABA antagonists. In: second edn.. Proc. B.P.S. 1976;p. 458P
  5. Chang YF, Gao XM, Chen JS. Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by l-lysine. Eur. J. Pharmacol. 1991;193:239–247
  6. Corda MG, Orlandi M, Lecca D, Carboni G, Frau V, Giorgi O. Pentylenetrazol-induced kindling in rats: effect of GABA function inhibitors. Pharmacol. Biochem. Behav. 1991;40:329–333
  7. Crain SM, Shen KF. After chronic opioid exposure sensory neurons become supersensitive to the excitatory effects of opioid agonists and antagonists as accurs after acute elevation of GM1 ganglioside. Brain Res. 1992;575:13–24
  8. Danks JA, Tortella FC, Long JB, Bykov V, Jacobson AE, Rice KC, et al. Chronic administration of morphine and naltrexone up-regulate [3H]-[d-Ala2, d-Leu5]-enkephalin binding sites by different mechanisms. Neuropharmacology. 1988;27:965–974
  9. De Vries TJ, Tjon Tien Ril GHK, Van der Laan JW, Mulder AH, Schoffermeer ANM. Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu opioid receptor sensitivity. Life Sci. 1993;52:1685–1693
  10. Engel J, Ackermann RF. Interictal EEG spikes correlate with decreased, rather than increased, epileptogenicity in amygdaloid kindled rats. Brain Res. 1980;190:543–548
  11. Freedman JE, Aghajanian GK. Opiate and alfa2-adrenoreceptor responses of rat amygdaloid neurons: co-localization and interactions during withdrawal. J. Neurosci. 1985;5:3016–3024
  12. Gall CM. Regulation of brain neurotrophin expression by physiological activity. Trends Pharm. Sci. 1992;13:401–403
  13. Guitar X, Nestler EJ. Second messenger and protein phosphorilation mechanism underlying opiate addiction: studies in the rat locus coeruleus. Neurochem. Res. 1993;18:5–13
  14. Hong M, Milne B, Jhamadas K. Evidence for the involvement of excitatory amino acid pathways in the development of precipitated withdrawal from acute and chronic morphine: an in vivo voltammetric study in the rat locus coeruleus. Brain Res. 1993;623:131–141
  15. Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science. 1988;242:715–723
  16. Lopez F, Miller GL, Thompson ML, Schatzki A, Chesley S, Greenblatt DJ, et al. Chronic morphine administration augments benzodiazepine binding and GABAa receptor function. Psychopharmacology. 1990;101:545–549
  17. Martin WR, Jasinski DR, Haertzen CA, Kay DC, Jones BE, Mansky PA, et al. Methadone—A revaluation. Arch. Gen. Psychiatry. 1973;28:286–295
  18. Mody I. The molecular basis of kindling. Brain Pathol. 1993;3:395–403
  19. Nestler EJ, Hope BT, Widell KL. Drug addiction: a model for the molecular basis of neural plasticity. Neuron. 1993;11:995–1006
  20. Nobrega JN, Kish SJ, McIntryre-Burnham W. Autoradiographic analysis of benzodiazepine binding in entorhinal-kindled rat brains. Brain Res. 1989;498:315–322
  21. Olsen RW, Wamsley JK, Lee RJ, Lomax P. Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy. Adv. Neurol. 1986;44:365–378
  22. Paxinos G, Watson C. In:  Paxinos G editors. The Rat Brain in Stereotaxic Coordinates. London: Academic Press; 1986;
  23. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroenceph. Clin. Neurophysiol. 1972;32:281–294
  24. Rocha L, Engel J, Ackermann RF. Effects of chronic naloxone pretreatment on amygdaloid kindling in rats. Epilepsy Res. 1991;10:103–110
  25. Rocha L, Tatsukawa K, Chugani HT, Engel J. Benzodiazepine receptor binding following chronic treatment with naloxone, morphine and met-enkephaline in normal rats. Brain Res. 1993;612:247–252
  26. Rocha L, Engel J, Ackermann RF, Chugani HT. Chronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled rats. Epilepsy Res. 1994;17:135–142
  27. Rothman RB, Bykov V, Long JB, Brady LS, Jacobson AR, Rice KC, et al. Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by 3H-d-Ala2, MePhe4, Gly-o15 enkephalin: further evidence for two mu-binding sites. Eur. J. Pharmacol. 1989;160:71–82
  28. Shin C, Pederson HB, McNamara JO. Gammaaminiobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. J. Neurosci. 1985;5:2696–2701
  29. Shinoda H, Nadi NS, Schwartz JP. Alterations in somatostatin and proenkephalin mRNA in response to a single amygdaloid stimulation versus kindling. Mol. Brain Res. 1991;11:221–226
  30. Sivam SP, Nabeshima T, Ho IK. An analysis of GABA receptor changes in the discrete regions of mouse brain after acute and chronic treatments with morphine. J. Neurochem. 1982;39:933–939
  31. Skerritt JH, Johnston GAR. Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur. J. Pharmacol. 1983;89:193–198
  32. Tallman JF. Modulation of the pharmacological sites of benzodiazepine action. In:  Biggio G,  Costa E editor. Chloride Channels and Their Modulation by Neurotransmitters and Drugs. New York: Raven Press; 1988;p. 19–25
  33. Tuff LP, Racine RJ, Adamec R. The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression. Brain Res. 1983;277:79–90
  34. Tuff LP, Racine RJ, Mishra RK. The effect of kindling on GABA-mediated inhibition in the dentate gyrus of the rat: II. Receptor binding. Brain Res. 1983;277:91–98

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Epilepsy Research
Volume 23, Issue 3 , Pages 225-233 , April 1996