Epilepsy Research
Volume 23, Issue 2 , Pages 123-127, March 1996

Lack of hippocampal involvement in a rat model of petit mal epilepsy

  • Adam Kandel
    • ,
  • Anatol Bragin
    • ,
  • Daniel Carpi
    • ,
  • György Buzsáki

      Affiliations

    • Corresponding Author InformationCorresponding author. Center for Molecular and Behavioral Neuroscience, Rutgers, the State University of New Jersey, 197 University Ave, Newark, NJ 07102, USA. Tel: (201) 648-1080 x3131; fax: (201) 638-1588

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA

Accepted 30 October 1995.

Abstract 

Although petit mal epilepsy is believed to arise from the thalamocortical system, it has been suggested recently that high-voltage spike-and-wave activity (HVS) in mutant mice can cause structural reorganization in the hippocampus, similar to that seen in temporal lobe epilepsy. We tested this assumption in rat strains with low and high incidence of HVS. No relationship was found between mossy fiber sprouting and HVS incidence. Hippocampal neurons were not driven by HVS. These findings suggest that petit mal seizures do not invade the hippocampus and are not causally related to sprouting of the mossy fibers.

Keywords:  Petit mal epilepsy, Hippocampus, Rat model, High-voltage spike-and-wave activity

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PII: 0920-1211(95)00097-6

Epilepsy Research
Volume 23, Issue 2 , Pages 123-127, March 1996

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