Epilepsy Research
Volume 23, Issue 2 , Pages 129-137 , March 1996

Felbamate monotherapy has stimulant-like effects in patients with epilepsy

  • T.A. Ketter

      Affiliations

    • Corresponding Author InformationCorresponding author. Biological Psychiatry Branch, NIMH, Building 10, Room 3N212, 9000 Rockville Pike, Bethesda, MD 20892, USA. Tel.: (301) 496-6826; fax (301) 402-0052.
    • Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
  • ,
  • B.A. Malow

      Affiliations

    • Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
  • ,
  • R. Flamini

      Affiliations

    • Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
  • ,
  • D. Ko

      Affiliations

    • Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
  • ,
  • S.R. White

      Affiliations

    • Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
  • ,
  • R.M. Post

      Affiliations

    • Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
  • ,
  • W.H. Theodore

      Affiliations

    • Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

Received 27 March 1995 ,Revised 15 August 1995 ,Accepted 15 September 1995.

References 

  1. Baldwin MA, Cuestas M, Talwar D. Tolerability of felbamate in children. In: Annual Meeting of the American Epilepsy Society. New Orleans, December 2–8, 1994. fourth edition. Epilepsia. 35:1994;p. 121; abstract 5.30
  2. Bourgeois B, Leppik IE, Sackellares JC, Laxer K, Lesser R, Messenheimer JA, et al. Felbamate: A double-blind controlled trial in patients undergoing presurgical evaluation of partial seizures. Neurology. 1993;43:693–696
  3. Bunney WE, Hamburg DA. Methods for reliable longitudinal observation of behavior. Arch. Gen. Psychiatry. 1963;9:280–294
  4. Cereghino JJ. Clinical trial design for antiepileptic drugs. (editorial) Ann. Neurol. 1992;32:393–394
  5. In: fourth edition. Diagnostic and Statistical Manual of Mental Disorders. Washington: American Psychiatric Association; 1994;
  6. Faught E, Sachdeo RC, Remler MP, Chayasirisobhon S, Iragui-Madoz VJ, Ramsay RE, et al. Felbamate monotherapy for partial-onset seizures: An active-control trial. Neurology. 1993;43:688–692
  7. Guy W. The Clinical Global Impression (CGI) scale. In:  Guy W editors. ECDEU Assessment Manual for Psychopharmacology. 2nd ed.. DHEW Publication No. ADM 76-338. Rockville, MD: U.S. Department of Health, Education, and Welfare; 1976;p. 218–222 revised
  8. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry. 1960;12:56–62
  9. Kanner AM, Ristanovic R, Smith M, Bergen D, Pierre-Louis SJC, Frey M. Acute depressive disorder following a three week switch-over to felbamate: A controlled study. In: Annual Meeting of the American Epilepsy Society. New Orleans, December 2–8, 1994. 2nd ed.. Epilepsia. 35:1994; abstract 4.14
  10. Ketter TA, Malow BA, Flamini R, White SR, Post RM, Theodore WH. Anticonvulsant withdrawal-emergent psychopathology. Neurology. 1994;44:55–61
  11. Luciano D, Devinsky O, Raguthu S, Kutscher M, Frontera A. Movement disorders during felbamate therapy. In: Annual Meeting of the American Epilepsy Society. New Orleans, December 2–8, 1994. 2nd ed.. Epilepsia. 35:1994;p. 159; abstract 6.56
  12. McCabe RT, Wasterlain CG, Kucharczyk N, Sofia RD, Vogel JR. Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. J. Pharmacol. Exp. Ther. 1993;264:1248–1252
  13. Mele A, Thomas DN, Pert A. Fundamentally different mechanisms underlie the locomotor stimulatory actions of dopamine agonists and MK-801. In: Society for Neuroscience 1994 Annual Meeting. Miami Beach. November 13–18, 1994;
  14. Overall JE, Gorham DR. The brief psychiatric rating scale (BPRS): Recent developments in ascertainment and scaling. Psychopharmacol. Bull. 1988;24:97–99
  15. Palmer KJ, McTavish D. Felbamate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in epilepsy. Drugs. 1993;45:1041–1065
  16. Post RM, Altshuler LL, Ketter TA, Denicoff K, Weiss SR. Antiepileptic drugs in affective illness. Clinical and theoretical implications. In:  Smith DB,  Treiman DM,  Trimble MR editor. Neurobehavioral Problems in Epilepsy. 2nd ed.. Advances in Neurology. Vol. 55:New York: Raven Press; 1991;p. 239–277
  17. Rho JM, Donevan SD, Rogawski MA. Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-d-aspartate and gamma-aminobutyric acidA receptors. Ann. Neurol. 1994;35:229–234
  18. Rho JM, Donevan SD, Rogawski MA. Effects of the dicarbamates felbamate and meprobamate on GABA-activated Cl currents in cultured rat hippocampal neurons. In: 46th Annual Meeting of the American Academy of Neurology. Washington, May 1–7, 1994. 2nd ed.. Neurology. 44:1994;p. A237; abstract 443P
  19. Rho JM, Donevan SG, Rogawski MA. Characterization of felbamate's actions on NMDA and GABA receptors in cultured rat hippocampal neurons. Soc. Neurosci. Abstr. 1993;19:1632; (abstract 688.13)
  20. Sachdeo R, Kramer LD, Rosenberg A, Sachdeo S. Felbamate monotherapy: Controlled trial in patients with partial onset seizures. Ann. Neurol. 1992;32:386–392
  21. Schneier FR, Liebowitz MR, Davies SO, Fairbanks J, Hollander E, Campeas R, et al. Fluoxetine in panic disorder. J. Clin. Psychopharmacol. 1990;10:119–121
  22. The Felbamate Study Group in Lennox-Gastaut Syndrome. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). N. Engl. J. Med. 1993;328:29–33
  23. Theodore WH, Albert P, Stertz B, Malow BA, Ko D, White SR, et al. Felbamate monotherapy: implications for antiepileptic drug development. Epilepsia. 1995;36:1105–1110
  24. In:  Theodore WH,  Devinsky O editor. Epilepsy and Behavior. New York: Wiley-Liss; 1991;
  25. Theodore WH, Raubertas RF, Porter RJ, Nice F, Devinsky O, Reeves P, et al. Felbamate: A clinical trial for complex partial seizures. Epilepsia. 1991;32:392–397
  26. White HS, Wolf HH, Swinyard EA, Skeen GA, Sofia RD. A neuropharmacological evaluation of felbamate as a novel anticonvulsant. Epilepsia. 1992;33:564–572
  27. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: Reliability, validity and sensitivity. Br. J. Psychiatry. 1978;133:429–435
  28. Zung WW. A rating instrument for anxiety disorders. Psychosomatics. 1971;12:371–379

 Presented in part at the American Epilepsy Society Annual Meeting, New Orleans, December 1994.

PII: 0920-1211(95)00089-5

Epilepsy Research
Volume 23, Issue 2 , Pages 129-137 , March 1996