Epilepsy Research
Volume 23, Issue 1 , Pages 71-76 , February 1996

Effect of a high-protein meal on gabapentin pharmacokinetics

  • Barry E. Gidal

      Affiliations

    • Corresponding Author InformationCorresponding author. School of Pharmacy and Department of Neurology, University of Wisconsin-Madison, 425 N. Charter Street, Madison, WI 53706, USA. Tel.: (608) 262-3280; fax: (608) 265-5421.
    • University of Wisconsin, School of Pharmacy, Madison, WI, USA
    • University of Wisconsin, Department of Neurology, Madison, WI, USA
    • ,
  • Melissa M. Maly

      Affiliations

    • University of Wisconsin, Department of Neurology, Madison, WI, USA
    • ,
  • Jim Budde

      Affiliations

    • University of Wisconsin, School of Pharmacy, Madison, WI, USA
    • ,
  • Gary L. Lensmeyer

      Affiliations

    • University of Wisconsin, Department of Laboratory Medicine, Madison, WI, USA
    • ,
  • Michael E. Pitterle

      Affiliations

    • University of Wisconsin, School of Pharmacy, Madison, WI, USA
    • ,
  • John C. Jones

      Affiliations

    • University of Wisconsin, Department of Neurology, Madison, WI, USA

Received 17 April 1995 ,Revised 15 July 1995 ,Accepted 20 July 1995.

References 

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  2. In:  Pennington JAT editors. Bowes and Churches Food Values of Portions Commonly Used. 16th ed.. Philadelphia, PA: J.B. Lippincott Co; 1994;
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  5. Killberg MS, Stevens BR, Novak DA. Recent advances in mammalian amino acid transport. Ann. Rev. Nutr. 1993;13:137–165
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  7. Lensmeyer G, Kempf T, Gidal B, Weibe D. Optimized method for determination of gabapentin in serum by HPLC. Ther. Drug Monit. 1995;17:251–258
  8. McLean MJ. Clinical pharmacokinetics of gabapentin. Neurology. 1994;44(Suppl. 5):S17–S22
  9. Pardridge WM, Choi TB. Neutral amino acid transport at the human blood-brain barrier. In: Fed. Proc. 45:1986;p. 2073–2078
  10. Pinchus JH, Barry KM. Plasma levels of amino acids correlate with motor fluctuations in Parkinsonism. Arch. Neurol. 1987;44:1006–1009
  11. Riley D, Lang AE. Practical application of a low protein diet for Parkinsons disease. Neurology. 1988;38:1026–1031
  12. Shulkin BL, Betz AL, Koeppe RA, Agranoff BW. Inhibition of neutral amino acid transport across the human blood-brain barrier by phenylalanine. J. Neurochem. 1995;64:1252–1257
  13. Stevens BR. Vertebrate intestine apical membrane mechanisms of organic nutrient transport. Am. J. Physiol. 1992;263(32):R458–R463
  14. Stevens BR. Amino acid transport in intestine. In:  Killberg MS,  Haussinger D editor. Mammalian Amino Acid Transport. New York: Plenum Press; 1992;
  15. Stewart BH, Kugler AR, Thompson PR, Bockbrader HN. A saturable transport mechanism in intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm. Res. 1993;10(2):276–282
  16. Thurlow RJ, Brown JP, Gee NS, Hill DR, Woodruff GN. [3H]Gabapentin may label a system-L like neutral amino acid carrier in brain. Eur. J. Pharmacol. 1993;247:341–345
  17. Welling PG. Interactions affecting drug absorption. Clin. Pharmacokin. 1984;9:404–434
  18. Welty DF, Schielke GP, Vartanian MG, Taylor CP. Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate. Epilepsy Res. 1993;16:175–181

PII: 0920-1211(95)00051-8

Epilepsy Research
Volume 23, Issue 1 , Pages 71-76 , February 1996

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