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Epilepsy Research
Volume 22, Issue 2
, Pages 65-95
, October 1995
Cognitive side-effects of chronic antiepileptic drug treatment: A review of 25 years of research
References
- . Chronic antiepileptic toxicity: A review. Epilepsia. 1975;16:319–352
-
.
Behavioral effects of antileptic drugs.
In: 2nd edn..
Smith D, Treiman D, Trimble M editor.
Advances in Neurology. Vol. 55:New York: Raven Press; 1991;p. 213–224
-
.
Cognitive effects of antiepileptic drugs.
In:
Devinski O, Theodore W editor. Epilepsy and Behavior. New York: Wiley-Liss; 1991;p. 151–170
-
.
Statistical Power Analysis for the Behavioral Sciences.
New York: Academic Press; 1977;
- . Carbamazepine: A neuropsychological and psychiatric profile. Clin. Neuropharmacol. 1985;8(3):221–241
- Behavioral toxicity associated with antiepileptic drugs: Concepts and methods of assessment. Epilepsia. 1986;27(4):331–340
- . Psychotropic effect of antiepileptic drugs. Acta Neurol. Scand. 1979;60:329–343
- . Psychopharmacological aspects of antiepileptic treatment. Prog. Neurobiol. 1980;15:119–138
-
.
Cognitive effects of antiepileptic drugs.
In: 2nd edn..
Smith D, Treiman D, Trimble M editor.
Advances in Neurology. Vol. 55:New York: Raven Press; 1991;p. 197–212
-
.
Anticonvulsant drugs and psychosocial development: Phenobarbitone, sodium valproate, and benzodiazepines.
In:
Morselli PL, Pippenger CE, Penry JK editor. Antiepileptic Drug Therapy in Pediatrics. New York: Raven Press; 1983;p. 201–217
-
.
Anticonsulvant drugs and cognitive function: A review of the literature.
Epilepsia. 1987;28(Suppl. 3):37–45
-
.
Anticonvulsant drugs: Mood and cognitive function.
In:
Trimble MR, Reynolds EH editor. Epilepsy, Behavior and Cognitive Function. Chichester: John Wiley & Sons; 1987;p. 135–145
- . Children of school age: The influence of antiepileptic drugs on behavior and intellect. Epilepsia. 1988;29(Suppl. 3):S15–S19
-
.
Memory, anticonvulsant drugs and seizures.
Acta Neurol. Scand. 1981;63:31–41
- . Anticonvulsant drugs, cognitive function and behaviour. Epilepsia. 1983;24(Suppl. 1):S55–S63
-
.
Sodium valproate and cognitive function.
Epilepsia. 1984;25(Suppl. 1):60–64
-
.
Anticonvulsant drugs, cognitive function and behaviour.
In:
Ross E, Reynolds EH editor. Paediatric Perspectives on Epilepsy. Chichester: John Wiley & Sons; 1985;p. 141–148
-
.
Anticonvulsant drugs and cognitive abilities.
In:
Canger R, Angeleri F, Penry JK editor. Advances in Epileptology. New York: Raven Press; 1980;p. 199–204
- Meta-analyses of randomized controlled trials. N. Engl. J. Med. 1987;316(8):450–455
- . Neurobehavioural effects of phenytoin, carbamazepine, and valproic acid: Implications for use in traumatic brain injury. Arch. Phys. Med. Rehabil. 1995;72:219–226
- Side effects of phenobarbital in toddlers: Behavior and cognitive aspects. J. Pediatr. 1979;95:361–365
- Long-term effect of phenobarbital on cognitive function in children with febrile convulsions. Pediatrics. 1981;68(6):820–823
-
Phenobarbital for febrile seizures—Effects on intelligence and on seizure recurrence.
New Engl. J. Med. 1990;322(6):364–369
- . Motor speed is a contaminating factor in evaluating the ‘cognitive’ effects of phenytoin. Epilepsia. 1989;30:453–457
- . Neuropsychological effects of carbamazepine and phenytoin: A reanalysis. Neurology. 1991;41:141–143
- . Diphenylhydantoin serum levels, toxicity and neuropsychological performance in patients with epilepsy. Epilepsia. 1975;16:593–600
- . Psychotropic effects of carbazepine in epilepsy: A double-blind comparison with phenytoin. Neurology. 1977;27:1023–1028
- Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia. 1993;34(1):153–157
- Withdrawal of antiepileptic medication in children—Correlation of cognitive function and plasma concentration—The multicentre ‘Holmfrid’ study. Epilepsy Res. 1994;19:141–152
- Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology. 1991;41:1537–1540
- Withdrawal of antiepileptic medication—Effects on cogntive function in children—The results of the multicentre ‘Holmfrid’ study. Neurology. 1993;43(1):41–51
- . Anticonvulsant drugs and cognitive functions. Epilepsia. 1982;33:531–534
-
.
Further studies on anticonvulsant drugs and seizures.
Acta Neurol. Scand. 1980;60:51–58
- Behavioral and psychological studies: Acute effects of diphenylhydantoin in relation to plasma levels. Psychol. Med. 1972;2:111–120
- . Differences in the central actions of phenytoin and phenobarbitone in man, measured by critical flicker fusion treshold. Eur. J. Clin. Pharmacol. 1973;6:57–60
- . Has sodium valproate hypnotic effects?. Epilepsia. 1976;17:367–370
- Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam. Br. J. Clin. Pharmacol. 1985;20:619–629
- Effect of carbamazepine on psychomotor performance in naive subjects. Eur. J. Clin. Pharmacol. 1986;30:37–42
- Psychophysiological and psychometric studies after manipulating the GABA system by vigabatrin, a GABA-transaminase inhibitor. Int. J. Psychophysiol. 1986;4:63–80
- . Computer analysis of saccadic eye movements: Assessment of two different carbamazepine formulations. Eur. J. Clin. Pharmacol. 1989;37:513–516
- Effect of acute doses of controlled-release carbamazepine on clinical, psychomotor, electrophysiological and cognitive parameters of brain function. Epilepsia. 1992;33(2):335–342
- Effects of oxcarbazepine and carbamazepine on the central nervous system: Computerized analysis of saccadic and smooth pursuit eye movements. Acta. Neurol. Scand. 1992;85:425–429
- . A controlled comparison of the effect of diphenylhydantoin and placebo on mood and psychomotor functioning in normal volunteers. J. Clin. Pharmacol. 1974;14:543–551
- . Effects of diphenylhydantoin on mental abilities in the elderly. J. Am. Geriatr. Soc. 1975;23:207–211
-
.
Anticonvulsant drugs, cognitive function and memory.
Acta Neurol. Scand. 1980;23:207–211
- . Phenytoin and cognitive functions: Effects on normal volunteers and implications for epilepsy. Br. J. Clin. Psychol. 1981;20:155–162
- . Sodium valproate en cognitive functioning in normal volunteers. Br. J. Clin. Pharmacol. 1981;12:819–824
- . Memory and psychomotor effects of oxcarbazepine in healthy human volunteers. Eur. J. Clin. Pharmacol. 1993;44(6):529–533
-
.
Applied Multiuariate Analysis for the Social Sciences.
Hillsdale: Lawrence Erlbaum Associates; 1992;
-
.
The evaluation of the behavioral effects of antiepileptic drugs in animals and man.
In:
Kulig BM, Meinardi H, Stores G editor. Epilepsy and Behauior. Lisse: Swets & Zetlinger; 1980;
- . Neuropsychological abilities before and after 5 years of stable antiepileptic drug therapy. Epilepsia. 1992;33(2):327–334
- . Serum anticonvulsant concentrations in epileptic patients with mental symptoms: A preliminary report. Br. J. Psychiatry. 1974;124:440–445
- . Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. Acta Neurol. Scand. 1975;52:319–330
- . Cognitive and motorsensory performances in toxic and nontoxic epileptic subjects. Neurology. 1975;25:184–188
- . Valproate sodium: Evaluation of so-called psychotropic effect. A controlled study. Epilepsia. 1977;18:159–162
- Clorazepate and phenobarbital as antiepileptic drugs: A double-blind study. Neurology. 1981;31(10):1271–1276
- . Anticonvulsant serum levels; relationship to impairments of cognitive functioning. J. Neurol. Neurosurg. Psychiatry. 1983;46:227–233
- . Behavioral and cognitive impairments in children with epilepsy: The long-term effects of anticonvulsant therapy. J. Am. Acad. Child Psychiatry. 1985;24:17–23
-
An improvement in cognitive function following polypharmacy reduction in a group of epileptic patients.
Acta Neur. Scand. 1985;71:448–452
- Zonisamide (CI-912) and cognition: Results from preliminary study. Epilepsia. 1987;28(1):61–67
-
Circumscribed improvement of cognitive performance in temporal lobe epilepsy patients with intractable seizures following reduction of anticonvulsants medication.
J. Epilepsy. 1989;2:147–153
- . Improvement in cognitive functioning and mood state after conversion to valproate monotherapy. Neurology. 1989;39:1640–1641
- . Effects of removal of phenytoin, carbamazepine and valproate on cognitive function. Epilepsia. 1990;31(5):584–591
- Event-related potentials and cognitive functions in epileptic treated patients. Clin. Electroencephalogr. 1990;21(2):67–73
- . Anticonvulsant drugs affect particular steps of verbal memory processing—An evaluation of 13 patients with intractable complex partial seizures of left temporal lobe origin. Neuropsychologia. 1992;30(7):623–631
- . Effects of vigabatrin on cognitive function and mood when used as add-on therapy in patients with intractable epilepsy. Epilepsia. 1992;33(1):128–134
- Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients. Epilepsy Res. 1992;11:193–198
- Effects of withdrawal of phenytoin on cognitive and psychomotor functions in hospitalized epileptic patients on polytherapy. Acta Neurol. Scand. 1992;86(2):165–170
- Carbamazepine (CBZ) controlled release compared with conventional CBZ: A controlled study of attention and vigilance in children with epilepsy. Epilepsia. 1992;33:1137–1144
- Effects of vigabatrin on sediation and cognitive function in patients with refractory epilepsy. J. Neurol. Neurosurg. Psychiatry. 1993;56:1271–1275
- Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia. 1993;34(2):312–322
- Evaluation of the effects of vigabatrin on cognitive abilities and quality of life in epilepsy. Neurology. 1993;43:2501–2507
- Discontinuation of clonazepam in patients with active epilepsy. Seizure. 1993;2:295–300
- . Verbal learning differences in epileptic patients with left and right temporal lobe fociA pharmacologically induced phenomenon?. Acta Neurol. Scand. 1993;87:1–8
- Effects of antiepileptic drugs on reaction time, attention and impulsivity in children. Pediatrics. 1993;91(1):101–105
- A doubleblind placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients. Br. J. Clin. Pharmacol. 1994;37:27–32
-
.
Phenytoin: Toxicity.
In:
Levy RH, Dreifuss FE, Mattson RH, et al. editor. Antiepileptic Drugs. New York: Raven Press; 1989;p. 241–256
- . Anticonvulsants, folic acid and memory dysfunction in epileptics. Clin. Exp. Neurol. 1985;20:57–62
- The influence of carbamazepine and phenytoin on memory and other aspects of cognitive function in new referrals with epilepsy. Acta Neurol. Scand. 1984;69(S.99):23–30
- A comparative study of the cognitive effects of phenytoin and carbamazepine in new referrals with epilepsy. Epilepsia. 1986;27:128–134
- Psychomotor impairment and anticonvulsant therapy in adult epileptic patients. Eur. J. Clin. Pharmacol. 1987;31:655–660
-
Concentration-effect relationships with carbamazepine and its epoxide on psychomotor and cognitive function in epileptic patients.
J. Neurosurg. Psychiatry. 1988;51:929–933
- Cognitive function in adult epileptic patients established on anticonvulsant monotherapy. Epilepsy Res. 1990;7:219–225
-
Cognitive function in adult epileptic patients on long-term sodium valproate.
In: Epilepsy. New York: Demos Publications; 1991;p. 205–210
-
Cognitive function of epileptic patients on monotherapy with phenobarbitone and healthy controls.
Arq. Neuro-Pslquiatr. 1991;49(2):136–141
- Cognitive functions, epileptic syndromes and antiepileptic drugs. Arq. Neuro-Psiquiatr. 1992;50(1):24–30
- . Carbamazepine offers no psychotropic advantage over phenytoin in adult epileptic subjects. Seizure. 1993;2:53–56
- Cognitive side-effects of phenytoin compared with carbamazepine in patients with localization-related epilepsy. Epilepsy Res. 1994;19:37–43
-
.
Quasi-Experimentation: Design & Analysis Issues for Field Settings.
Boston: Houghton Mifflin Company; 1979;
-
.
Problems in the assessment of cognitive effects of antiepileptic drugs.
Epilepsia. 1992;33(Suppl. 6):S29–S32
-
.
Experimental Design: Procedures for the Behavioral Sciences.
Belmont: Wadsworth Inc; 1982;
-
.
Differential Psychology: Individual and Group Differences in Behavior.
New York: The Macmillan Company; 1958;
- Ethosuximide in the treatment of absence (petit mal) seizures. Neurology. 1975;25:515–524
- . Serum phenytoin concentration and clinical response in patients with epilepsy. Br. J. Clin. Pharmacol. 1981;12:833–839
- . Anticonvulsant effects on the memory performance of epileptics. Clin. Exp. Neurol. 1984;20:27–35
- Zonisamide in epilepsy: A pilot study. Epilepsia. 1985;26:212–220
- Controlled release carbamazepine: Cognitive side-effects in patients with epilepsy. Epilepsia. 1987;28:507–514
- . Carbamazepine versus phenobarbital for partial onset seizures in children. Epilepsia. 1987;28:56–60
- Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin and primidone. Epilepsia. 1987;28(Suppl. 3):S50–S58
- . Memory impairment in epileptic patients: Selective effects of phenobarbital concentration. Science. 1978;202:1102–1104
- Controlled evaluation of a supplementary dose of carbamazepine on psychomotor function in epileptic patients. Eur. J. Clin. Pharmacol. 1986;31:195–199
- Effect of sodium valproate on psychomotor performance in children as a function of dose, fluctuations in concentration and diagnosis. Epilepsia. 1987;28:115–124
- Carbamazepine plasma concentration. Relationship to cognitive impairment. Arch. Neurol. 1987;44:863–867
- Effects of carbamazepine on psychomotor performance in children as a function of drug concentration, seizure type and time of medication. Epilepsia. 1990;31:51–60
- Cognitive function and time-of-day variation in serum carbamazepine concentration in epileptic patients treated with monotherapy. Epilepsia. 1991;32:116–121
- Conventional and controlled release valproate in children with epilepsy: A cross-over study comparing plasma levels and cognitive performance. Epilepsy Res. 1992;13:245–253
- . Rapid tolerance to acute psychomotor impairment with carbamazepine in epileptic patients. Br. J. Clin. Pharmacol. 1992;33:111–114
- . Memory effects following carbamazepine monotherapy in patients with complex partial epilepsy. Seizure. 1992;1:247–253
- Double dummy comparison between once and twice daily dosing with modified-release carbamazepine in epileptic patients. Br. J. Clin. Pharmacol. 1993;36:257–261
- Effects of phenytoin on cognitive-motor performance in children as a function of drug concentration, seizure type and time of medication. Epilepsia. 1994;35:172–180
-
Psychologic and behavioral effects of antiepileptic drugs in children: A double-blind comparison between phenobarbital and valproic acid.
Pedriatics. 1987;80(2):165–174
- Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children. Acta Neurol. Scand. 1990;81:504–506
- Comparative cognitive effects of anticonvulsants. Neurology. 1990;40:391–394
- Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. Dev. Med. Child Neurol. 1991;33:524–534
- Cognitive effects of oxcarbazepine and phenytoin monotherapy in newly diagnosed epilepsy: One year follow-up. Epilepsy Res. 1992;11(3):199–203
- Carbamazepine and phenytoin in epilepsies refractory to bartiburates: Efficacy, toxicity and mental function. Epilepsy Res. 1993;16:147–155
- . Differential effects of first antiepileptic drug application on cognition in lesional and non-lesional patients with epilepsy. Seizure. 1993;2:125–130
- . Impact of valproate and phenytoin on cognitive function in elderly patients: Results of a single-blind randomized comparative study. Epilepsia. 1994;35:381–390
- . Effects of phenytoin and carbamazepine on cognitive functions in newly diagnosed epileptic patients. Acta Neurol. Scand. 1994;89:81–86
- Withdrawal of phenobarbital and carbamazepine in epileptic patients: A preliminary neuropsychological report. Acta Neurol. Scand. 1986;74:59–62
- Cognitive effects of phenytoin during monotheraphy and after withdrawal. Acta Neurol. Scand. 1987;75:258–261
- Carbamazepine and phenytoin. Comparison of cognitive effects in epileptic patients during monotherapy and withdrawal. Arch. Neurol. 1988;45:892–894
- Cognitive effects of valproate. Epilepsy Res. 1990;5:160–164
-
Cognitive effects of antiepileptic drug discontinuation.
Epilepsia. 1992;33(Suppl. 6):S41–844
-
.
How to use antiepileptic drugs.
In:
Levy RH, Dreifuss FE, Mattson RH editor. Antiepileptic Drugs. New York: Raven Press; 1989;p. 117–132
- . Cognitive effects of anticonvulsants [Letter]. Neurology. 1991;41:1326
- . Comments on: ‘Differential effects of first antiepileptic drug application in lesional and non-lesional patients with epilepsy’. Seizure. 1993;2:311–313
- . Relapse following discontinuation of antiepileptic drugs: A meta-analysis. Neurology. 1994;44:601–608
-
.
Effects of antiepileptic drugs on the developing central nervous system.
In: 2nd edn..
Smith D, Treiman D, Trimble M editor.
Advances in Neurology. Vol. 55:New York: Raven Press; 1991;p. 225–237
- . Suspended judgement. Treatment effect size in clinical trials: An example from surfactant trials. Control. Clin. Trials. 1993;14:467–470
PII: 0920-1211(95)00047-X
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Epilepsy Research
Volume 22, Issue 2
, Pages 65-95
, October 1995
