Epilepsy Research
Volume 21, Issue 3 , Pages 231-236 , July 1995

Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures

  • Elinor Flen-Menachem

      Affiliations

    • Corresponding Author InformationCorresponding author. Dept. of Neurology, Sahlgren University Hospital, 413 45 Göteborg, Sweden. Tel.: 46 31-601000; Fax: 46 31-211552.
    • Department of Neurology, University of Göteborg, Göteborg, Sweden
    • ,
  • Birgitta Söderfelt

      Affiliations

    • Department of Neurology, Linköpings University, Linköping, Sweden
    • ,
  • Anders Hamberger

      Affiliations

    • Department of Histology, University of Göteborg, Göteborg, Sweden
    • ,
  • Tomas Hedner

      Affiliations

    • Department of Pharmacology, University of Göteborg, Göteborg, Sweden
    • ,
  • Lennart I. Persson

      Affiliations

    • Department of Neurology, University of Göteborg, Göteborg, Sweden

Received 10 October 1994 ,Revised 16 March 1995 ,Accepted 2 April 1995.

References 

  1. Anhut H, Ashman P, Feuerstein TJ, Sauermann W, Saunders M, Schmidt B  International Gabapentin Study Group. Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: A double-blind, placebo-controlled study. Epilepsia. 1994;35:795–801
  2. Ben-Menachem E, Persson LI, Schechter PJ, Haegele KD, Huebert N, Hardenberg J, et al. Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy. Epilepsy Res. 1988;2:96–101
  3. Ben-Menachem E, Persson LI, Schechter PJ, Haegele KD, Huebert N, Hardenberg J, et al. The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients. Br. J. Clin. Pharmacol. 1989;27(suppl. 1):79–86
  4. Ben-Menachem E, Persson LI, Hedner T. CSF free and total GABA, homovanillic acid, 5-hydroxythryptophan, and 5-hydroxyindoleacetic acid and gabapentin concentrations in CSF and plasma in patients with intractable complex partial seizures after a single oral dose of gabapentin. Epilepsy Res. 1992;11:45–49
  5. Biswas B, Carlsson A. The effect of intracerebroventricularly administrated GABA on brain monoamine metabolism. Naunyn-Schmied. Arch. Pharmacol. 1977;299:41–46
  6. Chadwick D. Gabapentin. Lancet. 1994;343:89–91
  7. Grove J, Schechter PJ, Hanke NFJ, DeSmet Y, Agid Y, Tell G, et al. Concentration gradients of free and total gamma-aminobutyric acid and homocarnosine in the human CSF: Comparison of suboccipital and lumbar sampling. J. Neurochem. 1982;39:1618–1622
  8. Hamberger A, Nyström B, Larsson S, Silfvenius H, Nordborg C. Amino acids in the neuronal microenvironment of focal human epileptic lesions. Epilepsy Res. 1991;9:32–43
  9. Hengy H, Kölle E-U. Determination of gabapentin in plasma and urine by high-performance liquid chromatography and pre-column labelling for ultraviolet detection. J. Chromatogr. 1985;341:473–478
  10. Mefford IN. Applications of high performance liquid chromatography with electrochemical detection to neurochemical analysis: Measurement of catecholamines, serotonin and metabolites in rat brain. J Neurosci. Meth. 1981;3:207–224
  11. Ojeman LM, Friel PN, Ojeman GA. Gabapentin concentrations in human brain. Epilepsia. 1988;29:694
  12. Stewart BH, Kugler AR, Thompson PR, Bockbrader HN. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm. Res. 1993;10:276–281
  13. Suman-Chahan N, Webdale L, Hill DR, Woodruff GN. Characterization of (3H)gabapentin binding to a novel site in rat brain: Homogenate binding studies. Eur. J. Pharmacol. 1993;244:293–301
  14. The US Gabapentin Study Group No. 5. Gabapentin as add-on therapy in refractory partial epilepsy. A double-blind placebo-controlled, parallel-group study. Neurology. 1993;43:2292–2298
  15. Welty DF, Schielke GP, Vartanian MG, Taylor CP. Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate. Epilepsy Res. 1993;16:175–181

PII: 0920-1211(95)00026-7

Epilepsy Research
Volume 21, Issue 3 , Pages 231-236 , July 1995

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