Epilepsy Research
Volume 21, Issue 3 , Pages 195-204 , July 1995

An in vitro model of persistent epileptiform activity in neocortex

  • Vivian Valenzuela

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: (718) 270-1356; Fax: (718) 2703840.
    • Department of Neurology, State University of New York Health Science Center, 450 Clarkson Ave., Box 118, Brooklyn, NY 11203, USA
  • ,
  • Larry S. Benardo

      Affiliations

    • Department of Neurology, State University of New York Health Science Center, 450 Clarkson Ave., Box 118, Brooklyn, NY 11203, USA
    • Department of Pharmacology, State University of New York Health Science Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA

Received 26 October 1994 ,Accepted 20 March 1995.

References 

  1. Anderson WW, Swartzwelder HS, Wilson WA. The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. J. Neurophysiol. 1987;57:1–21
  2. Aram JA, Lodge D. Epileptiform activity induced by alkalosis in rat neocortical slices: Block by antagonists of N-methyl-d-aspartate. Neurosci. Lett. 1987;83:345–350
  3. Artola A, Singer W. Long-term potentiation and NMDA receptors in rat visual cortex. Nature. 1987;330:649–652
  4. Avoli M, Drapeau C, Louvel J, Pumain R, Olivier A, Villemure J-G. Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro. Ann. Neurol. 1991;30:589–596
  5. Benardo LS. Recruitment of inhibition by enhanced activation of synaptic NMDA responses in the rat cerebral cortex. Brain Res. 1993;627:314–324
  6. Benardo LS, Pedley TA. Cellular mechanisms of focal epileptogenesis. In:  Pedley TA,  Meldrum BS editor. Recent Advances in Epilepsy, Number Two. Edinburgh: Churchill Livingstone; 1985;p. 1–17
  7. Benninger C, Kadis J, Prince DA. Extracellular calcium and potassium changes in hippocampal slices. Brain Res. 1980;187:165–182
  8. Bliss TPV, Collingridge GL. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature. 1993;361:31–39
  9. Bliss TVP, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. 1973;232:331–356
  10. Davies SN, Lester RAJ, Reymann KG, Collingridge GL. Temporally distinct pre-and postsynaptic mechanisms maintain long-term potentiation. Nature. 1989;338:500–503
  11. Douglas RM, Goddard GV. Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus. Brain Res. 1975;86:205–215
  12. Futamachi KJ, Mutani R, Prince DA. Potassium activity in rabbit cortex. Brain Res. 1974;75:5–25
  13. Galvan M, Grafe P, ten Bruggencate G. Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice. Brain Res. 1982;241:75–86
  14. In:  Gastaut H,  Broughton R editor. Epileptic Seizures. Clinical and Electrographic Features, Diagnosis and Treatment. Springfield: Charles C. Thomas; 1972;p. 25
  15. Gean P-W, Shinnick-Gallagher P, Anderson AC. Spontaneous epileptiform activity and alteration of GABA-and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo. Brain Res. 1989;494:177–181
  16. Gutnick MJ, Connors BW, Prince DA. Mechanisms of neocortical epileptogenesis in vitro. J. Neurophysiol. 1982;48:1321–1335
  17. Hablitz JJ. Spontaneous ictal-like discharges and sustained potentials shifts in developing rat neocortex. J. Neurophysiol. 1987;58:1052–1065
  18. Herron CE, Williamson R, Collingridge GL. A selective N-methyl-d-aspartate antagonist depresses epileptiform activity in rat hippocampal slices. Neurosci. Lett. 1985;61:255–260
  19. Hoffman SN, Salin PA, Prince DA. Chronic neocortical epileptogenesis in vitro. J. Neurophysiol. 1994;71:1762–1773
  20. Hoffman WH, Haberly LB. Bursting induces persistent all-or-none EPSPs by an NMDA-dependent process in piriform cortex. J. Neurosci. 1989;9:206–215
  21. Jones RSG, Heinemann U. Synaptic and intrinsic responses of medial entorhinal cortical cells in normal and magnesium-free medium in vitro. J. Neurophysiol. 1988;59:1476–1496
  22. Kandel ER, Spencer WA. Excitation and inhibition of single pyramidal cells during hippocampal seizure. Exp. Neurol. 1961;4:162–179
  23. Lipton SA, Rosenberg PA. Excitatory aminoacids as a final common pathway for neurologic disorders. New Engl. J. Med. 1994;330:613–622
  24. Malenka RC, Nicoll RA. NMDA-receptor-dependent synaptic plasticity: Multiple forms and mechanisms. Trends Neurosci. 1993;16:521–526
  25. Martin D, McNamara JO, Nadler JV. Kindling enhances sensitivity of CA3 hippocampus pyramidal cells to NMDA. J. Neurosci. 1992;12:1928–1935
  26. McBain CJ, Boden P, Hill RG. The kainate/quisqualate receptor antagonist, CNQX, blocks the fast component of spontaneous epileptiform activity in organotypic cultures of rat hippocampus. Neurosci. Lett. 1988;93:341–345
  27. McIntyre D, Popham R. Persistence of spontaneous bursting after in vitro exposure to 0 Mg. Epilepsia. 1992;33(suppl. 1):31–32
  28. Mayer ML, Westbrook GL, Guthrie PB. Voltagedependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature. 1984;309:261–263
  29. Mody I, Heinemann U. NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Nature. 1987;326:701–704
  30. Mody I, Lambert JDC, Heinemann U. Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J. Neurophysiol. 1987;57:869–888
  31. Mody I, Stanton PK, Heinemann U. Activation of N-methyl-d-aspartate receptors parallels changes in cellular and synaptic properties of dentate gyrus granule cells after kindling. J. Neurophysiol. 1988;59:1033–1054
  32. Muller D, Joly M, Lynch G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science. 1988;242:1694–1697
  33. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature. 1984;307:462–465
  34. Prince DA. Neurophysiology of epilepsy. Ann. Rev. Neurosci. 1978;1:395–415
  35. Prince DA. Physiological mechanisms of focal epileptogenesis. Epilepsia. 1985;26(suppl. 1):3–14
  36. Prince DA, Futamachi KJ. Intracellular recordings from chronic epileptogenic foci in the monkey. Electroencephalogr. Clin. Neurophysiol. 1970;29:496–510
  37. Rafiq A, DeLorenzo RJ, Coulter DA. Generation adn propagation of epileptiform discharges in a combined entorhinal cortex/hippocampal slice. J. Neurophysiol. 1993;70:1962–1974
  38. Rainnie DG, Asprodini EK, Shinnick-Gallagher P. Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdala. J. Neurophysiol. 1992;67:443–454
  39. Schwartzkroin PA, Haglund MM. Spontaneous rhythmic synchronous activity in epileptic human and normal monkey temporal lobe. Epilepsia. 1986;27:523–533
  40. Schwartzkroin PA, Prince DA. Penicillin-induced epileptiform activity in the hippocampal in vitro preparation. Ann. Neurol. 1977;1:463–469
  41. Schwartzkroin PA, Turner DA, Knowles WD, Wyler AR. Studies of human and monkey “epileptic” neocortex in the in vitro slice preparation. Ann. Neurol. 1983;13:249–257
  42. Schwartzkroin PA, Wester K. Long-lasting facilitation of a synaptic potential following tetanization in the in vitro hippocampal slice. Brain Res. 1975;89:107–119
  43. Silva LR, Amitai Y, Connors BW. Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science. 1991;251:432–435
  44. Snow RW, Taylor CP, Dudek FE. Electrophysiological and optical changes in slices of rat hippocampus during spreading depression. J. Neurophysiol. 1983;50:561–572
  45. Sutor B, Hablitz JJ. EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-d-aspartate receptors in the generation of EPSPs. J. Neurophysiol. 1989;61:621–634
  46. Teyler TJ, DiScenna P. Long-term potentiation. Ann. Rev. Neurosci. 1987;10:131–161
  47. Thomson AM, West DC. N-Methylaspartate receptors mediate epileptiform activity evoked in some, but not all, conditions in rat neocortical slices. Neuroscience. 1986;19:1161–1177
  48. Traynelis SF, Dingledine R. Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J. Neurophysiol. 1988;59:259–276
  49. Treiman LJ, Treiman DM. Genetic aspects of epilepsy. In:  Wyllie E editors. The Treatment of Epilepsies: Principles and Practice. Philadelphia: Lea and Febiger; 1993;p. 145–156
  50. Valenzuela V, Benardo LS. Spontaneous seizure discharges persist in neocortical slices after exposure to magnesium-free solutions: Pharmacology of induction and maintenance. Epilepsia. 1993;34(suppl. 6):51
  51. Walther H, Lambert JDC, Jones RSG, Heinemann U, Hamon B. Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion in low magnesium medium. Neurosci. Lett. 1986;69:156–161
  52. Wong BY, Prince DA. The lateral spread of ictal discharges in neocortical brain slices. Epilepsy Res. 1990;7:29–39

PII: 0920-1211(95)00024-5

Epilepsy Research
Volume 21, Issue 3 , Pages 195-204 , July 1995