Epilepsy Research
Volume 21, Issue 3 , Pages 183-193 , July 1995

Effects of anticonvulsants in a novel operant learning paradigm in rats: Comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents

Received 26 September 1994 ,Accepted 20 March 1995.

References 

  1. Bushnell PJ. Behavioral effects of acute p-xylene inhalation in rats: autoshaping, motor activity, and reversal learning. Neurotoxicol. Teratol. 1989;10:569–577
  2. Garske GE, Palmer GC, Napier JJ, Griffith RC, Freedman LR, Harris EW, et al. Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat. Epilepsy Res. 1991;9:161–174
  3. Goa KL, Ross S, Chrisp P. Lamotrigine: A review of its pharmacologic properties and clinical efficacy in epilepsy. Drugs. 1993;46:152–176
  4. Goa KL, Sorkin EM. Gabapentin: A review of its pharmacologic properties and clinical potential in epilepsy. Drugs. 1993;46:409–427
  5. Koek W, Woods JH, Ornstein P. A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-APV. Psychopharmacology. 1987;91:297–304
  6. Kohrman MH. Cognitive and behavioral effects of anticonvulsants in children. In:  Lomax P,  Vaswell ES editor. Progress in Basic and Clinical Pharmacology. Basel: S. Karger; 1993;p. 114–133
  7. Kraft K, Lyon DO, Poling A. Effects of phenytoin on schedule-controlled performance of rats. Psychopharmacology. 1982;78:93–95
  8. Krsiak M, Sulcova A. Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression, and locomotion in mice. Psychopharmacology. 1990;101:396–402
  9. McEntree WJ, Crook TH. Glutamate: Its role in learning, memory, and the aging brain. Psychopharmacology. 1993;111:391–401
  10. McMillan DE, Hardwick WC, deCosta BR, Rice KC. Effects of drugs that bind to PCP and sigma receptors on punished responding. J. Pharmacol. Exp. Ther. 1991;258:1015–1018
  11. Ono N, Furukawa T. Central effects of clonazepam. Folia Pharmacol. Jap. 1976;72:297–312
  12. Palmer GC, Murray RJ, Wilson TCM, Eisman MS, Ray RK, Griffith RC, et al. Biological profile of the metabolites of the anticonvulsant remacemide. Epilepsy Res. 1992;12:9–20
  13. Palmer GC, Clark B, Hutchinson JB. Antiepileptic and neuroprotective potential of remacemide hydrochloride. Drugs Future. 1993;18:1021–1042
  14. Paule MG, Killam EK. Behavioral toxicity of chronic ethosuximide and sodium valproatc treatment in the epileptic baboon, papio papio. J. Pharmacol. Exp. Ther. 1986;238:32–38
  15. Picker M, Poling A. Effects of anticonvulsants on learning: Performance of pigeons under a repeated acquisition procedure when exposed to phenobarbital, clonazepam, valproic acid, ethosuximide and phenytoin. J. Pharmacol. Exp. Ther. 1984;230:307–316
  16. Picker M, Thomas J, Koch C, Poling A. Effects of phenytoin, phenobarbital, and valproic acid alone and in selected combinations on schedule-controlled behavior of rats. Pharmacol. Biochem. Behav. 1985;22:389–393
  17. Poling A, Picker M, Grossett D, Polder DV. Effects of valproic acid and ethosuximide on the responding of pigeons maintained under a multiple fixed-ratio fixed-interval schedule of food delivery. Pharmacol. Biochem. Behav. 1985;23:469–472
  18. Porter RHP, Greenamyre JT. Regional variations in the pharmacology of NMDA receptor channel blockers: Implications for therapeutic approach. J. Neurochem. 1995;64:614–623
  19. Reynolds EH. Mental effects of anti-epileptic medication, A review. Epilepsia. 1983;24:85–95
  20. Sagvolden T, Holth P. Slower acquisition of positively reinforced behavior following medial but not dorsolateral septal lesions in rats. Behav. Neurosci. 1986;100:330–336
  21. Schmidt B. Potential antiepileptic drugs: Gabapentin. In:  Levy R,  Mattson R,  Meldrum B,  Penry J,  Dreifuss F editor. Antiepileptic Drugs. 3rd edition. New York: Raven Press; 1989;p. 925–935
  22. Smith RD, Greselak ME, Coffin VL. Felbamate, a novel antiepileptic agent, does not affect cognition in rodents. Behav. Pharmacol. 1994;5:364–368
  23. Soubrie P, Kulkarni S, Simon P, Boissier JR. Effects des anxiolytiques sur la prise de nouriture de rats et de souris places en situation novelle ou familiere. Psychopharmacologia. 1975;452:203–210
  24. Sparber SB, Cohen CA, Messing RB. Reversal of a trimethyltin-induced learning deficit by desglycinamide-8-arginine vasopressin. Life Sci. 1988;42:171–177
  25. Subramaniam S, Donevan SD, Rogowski MA. 1,2-Diphenyl-2-propylamine, a major metabolite of the anticonvulsant remacemide, produces stereoselective block of NMDA receptor currents. Soc. Neurosci. Abstr. 1993;19:717
  26. Swinyard EA, Sofia RD, Kupferberg HJ. Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. Epilepsia. 1986;27:27–34
  27. Tiedtke PI, Bischoff C, Schmidt WJ. MK-801 induced stereotypy and its antagonism by neuroleptic drugs. J. Neural Transm. 1990;81:173–182
  28. Trimble MR, Reynolds EH. Neuropsychiatric toxicity of anticonvulsant drugs. In:  Matthews WB,  Glaser GH editor. Recent Advances in Clinical Neurology. Edinburgh: Churchill Livingstone; 1976;
  29. Watson PJ, Cox JS. An analysis of barbiturate-induced eating and drinking in the rat. Physiol. Psychol. 1976;86:930–941
  30. Willetts J, Balster RL, Leander JD. The behavioral pharmacology of NMDA receptor antagonists. Trends Pharmacol. Sci. 1990;11:423–428

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Epilepsy Research
Volume 21, Issue 3 , Pages 183-193 , July 1995

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